Breast cancer models
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Example: MX-1-GFP and –RFP
breast carcinoma growing on mammary fat pads of SCID
mouse. Whole-body image.
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Features
- Orthotopic transplantation of intact tissue
- Metastatic sites
- lymph nodes
- liver
- lung
- skeleton
- Estrogen-dependent
- Estrogen-independent
- Green Fluorescent Protein expression
- Red Fluorescent Protein expression
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- Fu, X., Le, P., and Hoffman, R.M. A metastatic
orthotopic-transplant nude-mouse model of human patient breast
cancer. Anticancer Res. 13, 901-904, 1993.[PDF]

- Kubota, T., Inoue, S., Furukawa, T., Ishibiki, K., Kitajima, M.,
Kawamura, E., and Hoffman, R.M. Similarity of serum – Tumor
pharmacokinetics of antitumor agents in man and nude mice.
Anticancer Res. 13, 1481-1484, 1993.[PDF]

- Li, X-M., Wang, J-W., An, Z., Yang, M. Baranov, E., Jiang, P.,
Sun, F-X., Moossa, A.R., and Hoffman, R.M. Optically imageable
metastatic model of human breast cancer. Clinical & Experimental
Metastasis, 19, 347-350, 2002.[PDF]

- John, C.M., Leffler, H., Kahl-Knutsson, B., Svensson, I., Jarvis,
G.A. Truncated Galectin-3 Inhibits Tumor Growth and Metastasis in
Orthotopic Nude Mouse Model of Human Breast Cancer. Clinical Cancer
Res. 9, 3808-3814, 2003 [PDF]
- Goodison, S., Kawai, K., Hihara, J., Jiang, P., Yang, M.,
Urquidi, V., Hoffman, R.M., and Tarin, D. Prolonged dormancy and
site-specific growth potential of cancer cells spontaneously
disseminated from non-metastatic breast tumors revealed by labeling
with green fluorescent protein. Clinical Cancer Res. 9, 3808-3814,
2003. [PDF]

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