Colon cancer models
Example: AC3488-GFP-tumor growing on colon and metastasized to liver and lymph nodes of nude mouse.Whole-body image.. Primary tumor - red arrow, liver metastases - white arrow, lymph node - yellow arrow.

Features
  • Orthotopic transplantation of intact tissue
  • Metastatic sites
    • lymph nodes
    • liver
    • lung
    • brain
  • Green Fluorescent Protein expression

1. Fu, X., Besterman, J.M., Monosov, A., and Hoffman, R.M. Models of human metastatic colon cancer in nude mice orthotopically constructed by using histologically intact patient specimens. Proc. Natl. Acad. Sci. USA 88, 9345-9349, 1991.

2. Fu, X., Herrera, H., Kubota, T., and Hoffman, R.M. Extensive liver metastasis from human colon cancer in nude and scid mice after orthotopic onplantation of histologically-intact human colon carcinoma tissue. Anticancer Res. 12, 1395-1398, 1992.

3. Furukawa, T., Kubota, T., Watanabe, M., Kuo, P.H., Kase, S., Saikawa, Y., Tanino, H., Teramoto, T., Ishibiki, K., Kitajima, M., and Hoffman, R.M. Immunochemotherapy prevents human colon cancer metastasis after orthotopic onplantation of histologically-intact tumor tissue in nude mice. Anticancer Res. 13, 287-291, 1993.

4. Kuo, T-H., Kubota, T., Watanabe, M., Fujita, S., Furukawa, T., Teramoto, T., Ishibiki, K., Kitajima, M., and Hoffman, R.M. Early resection of primary orthotopically-growing human colon tumor in nude mouse prevents liver metastasis: Further evidence for patient-like hematogenous metastatic route. Anticancer Res. 13, 293-298, 1993.

5. Furukawa, T., Kubota, T., Watanabe, M., Kuo, T-H., Nishibori, H., Kase, S., Saikawa, Y., Tanino, H., Teramoto, T., Ishibiki, K., and Kitajima, M. A metastatic model of human colon cancer constructed using cecal implantation of cancer tissue in nude mice. Jpn. J. Surg. 23, 420-423, 1993.

6. Wang, X., Fu, X., Brown, P.D., Crimmin, M.J., and Hoffman, R.M. Matrix metalloproteinase inhibitor BB-94 (Batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice. Cancer Res. 54, 4726-4728, 1994.

7. Togo, S., Shimada, H., Kubota, T., Moossa, A.R., Hoffman, R.M. “Seed” to “soil” is a return trip in metastasis. Anticancer Res. 15, 791-794, 1995.

8. Togo, S., Shimada, H., Kubota, T., Moossa, A.R., Hoffman, R.M. Host organ specifically determines cancer progression. Cancer Res. 55, 681-684, 1995.

9. Kuo, T-H., Kubota, T., Watanbe, M., Furukawa, T., Teramoto, T., Ishibiki, K., Kitajimi, M., Moossa, A.R., Penman, S., Hoffman, R.M. Liver colonization competence governs colon cancer metastasis. Proc. Natl. Acad. Sci. USA 92, 12085-12089, 1995.

10. Togo, S., Wang, X., Shimada, H., Moossa, A.R., and Hoffman, R.M. Cancer seed and soil can be highly selective: Human-patient colon tumor lung metastasis grows in nude mouse lung but not colon or subcutis. Anticancer Res. 15, 795-798, 1995.

11. Leff, D.N. MetaMouse models colon cancer metastasis with clinical potential. BioWorld Today 7, 1, January 8, 1996.

12. Murray, G., Duncan, M., O’Neil, P., Melvin, W., Fothergill, J. Matrix metalloproteinase-1 is associated with poor prognosis in colorectal cancer. Nature Medicine 2, 461-462, 1996.

13. An, Z., Wang, X., Willmott, N., Chander, S.K., Tickle, S., Docherty, A.J.P., Mountain, A., Millican, A.T., Morphy, R., Porter, J.R., Epemolu, R.O., Kubota, T., Moossa, A.R., and Hoffman, R.M. Conversion of highly malignant colon cancer from an aggesssive to a controlled disease by oral administration of a metalloproteinase inhibitor. Clinical & Experimental Metastasis 15, 184-195, 1997.

14. Sun, F-X., Sasson, A.R., Jiang, P., An, Z., Gamagami, R., Li, L., Moossa, A.R., and Hoffman, R.M. An ultra-metastatic model of human colon cancer in nude mice. Clinical & Experimental Metastasis 17, 41-48, 1999.

15. Sasson, A.R., Gamagami, R., An, Z., Wang, X., Moossa, A.R., and Hoffman, R.M. Cimetidine: An inhibitor or promoter of tumor growth? International Journal of Cancer 81, 835-838, 1999.

16. Rho, Y-S., Lee, K-T., Jung, J-C., Yoon, C., An, Z., Hoffman, R.M., and Chang, S-G. Efficacy of new platinum analog DPPE in an orthotopic nude mouse model of human colon cancer. Anticancer Res. 19, 157-162, 1999.

17. Rashidi, B., An, Z., Sun, F-X., Sasson, A., Gamagammi, R., Moossa, A.R., Hoffman, R.M. Minimal liver resection strongly stimulates the growth of human colon cancer in the liver of nude mice. Clinical & Experimental Metastasis 17, 497-500, 1999.

18. Rashidi, B., Sun, F-X., Jiang, P., An, Z., Gamagami, R., Moossa, A.R., and Hoffman, R.M. A nude mouse model of massive liver and lymph node metastasis of human colon cancer. Anticancer Res. 20, 715-722, 2000.

19. Rashidi, B., An, Z., Sun, F-X., Moossa, A.R., and Hoffman, R.M. Antimetastatic intraoperative chemotherapy of human colon tumors in the livers of nude mice. Clinical Cancer Res. 6, 2464-2468, 2000.

20. Rashidi, B., Gamagami, R., Sasson, A., Sun, F-X., Geller, J., Moossa, A.R., and Hoffman, R.M. An orthotopic mouse model of remetastasis of human colon cancer liver metastasis. Clinical Cancer Res. 6, 2556-2561, 2000.

 

ORGAN SPECIFIC MODELS