Lung cancer models
Example: H-460-GFP human lung carcinoma growing on lung of nude mouse. Whole-body image.

Example: H460-GFP human lung carcinoma metastasized to vertebral body of nude mouse

Example: Lewis lung carcinoma-GFP metastasized to brain of nude mouse.

Features
  • Orthotopic transplantation of intact tissue
  • Metastatic sites
    • lymph nodes
    • contralateral lung
    • kidney
    • skeleton
    • esophagus
    • diaphragm
    • brain
    • heart
  • Small-Cell Carcinoma
  • Non-Small Cell Carcinoma
  • Adenocarcinoma.
  • Green Fluorescent Protein expression

1. Wang, X., Fu, X., and Hoffman, R.M. A new patient-like metastatic model of human lung cancer constructed orthotopically with intact tissue via thoracotomy in immunodeficient mice. Int. J. Cancer 51, 992-995, 1992.

2. Kuo, T-H., Kubota, T., Watanabe, M., Furukawa, T., Kase, S., Tanino, H., Nishibori, K., Saikawa, Y., Teramoto, T., Ishibiki, K., Kitajima, M., and Hoffman, R.M. Orthotopic reconstitution of human small-cell lung carcinoma after intravenous transplantation in SCID mice. Anticancer Res. 12, 1407-1410, 1992.

3. Wang, X., Fu, X., and Hoffman, R.M. A patient-like metastasizing model of human lung adenocarcinoma constructed via thoracotomy in nude mice. Anticancer Res. 12, 1399-1402, 1992.

4. Wang, X., Fu, X., Kubota, T., and Hoffman, R.M. A new patient-like metastatic model of human small-cell lung cancer constructed orthotopically with intact tissue via thoracotomy in nude mice. Anticancer Res. 12, 1403-1406, 1992.

5. Kuo, T-H., Kubota, T., Watanabe, M., Furukawa, T., Kase, S., Tanino, H., Nishibori, H., Saikawa, Y., Ishibiki, K., Kitajima, M., and Hoffman, R.M. Site-specific chemosensitivity of human small-cell lung carcinoma growing orthotopically compared to subcutaneously in SCID mice: The importance of orthotopic models to obtain relevant drug evaluation data. Anticancer Res. 13, 627-630, 1993.

6. Astoul, P., Wang, X., and Hoffman, R.M. "Patient-like" nude- and SCID-mouse models of human lung and pleural cancer (Review). Int. J. Oncology 3, 713-718, 1993.

7. Astoul, P., Colt, H.G., Wang, X., and Hoffman, R.M. A “patient-like” nude mouse model of parietal pleural human lung adenocarcinoma. Anticancer Res. 14, 85-92, 1994.

8. Astoul, P., Colt, H.G., Wang, X., Boutin, C. and Hoffman, R.M. A “patient-like” nude mouse metastatic model of advanced human pleural cancer. Journal of Cellular Biochemistry 56, 9-15, 1994.

9. Astoul, P., Wang, X., Colt, H.G., Boutin, C., and Hoffman, R.M. A patient-like human malignant pleural mesothelioma nude-mouse model. Oncology Reports 3, 483-487, 1996.

10. Colt, H.G., Astoul, P., Wang, X., Yi, E.S., Boutin, C., and Hoffman, R.M. Clinical course of human epithelial-type malignant pleural mesothelioma replicated in an orthotopic-transplant nude mouse model. Anticancer Res. 16, 633-640, 1996.

11. An, Z., Wang, X., Astoul, P., Danays, T., Moossa, A.R., and Hoffman, R.M. Interferon gamma is highly effective against orthotopically-implanted human pleural adenocarcinoma in nude mice. Anticancer Res. 16, 2545-2551, 1996.

12. Olbina, G., Cieslak, D., Ruzdijic, S., Esler, C., An, Z., Wang, X., Hoffman, R., Seifert, W., and Pietrzkowski, Z. Reversible inhibition of IL-8 receptor B mRNA expression and proliferation in non-small cell lung cancer by antisense oligonucleotides. Anticancer Res. 16, 3525-3530, 1996.

13. Yang, M., Hasegawa, S., Jiang, P., Wang, X., Tan, Y., Chishima, T., Shimada, H., Moossa, A.R., and Hoffman, R.M. Widespread skeletal metastatic potential of human lung cancer revealed by green fluorescent protein expression. Cancer Res. 58, 4217-4221, 1998.

14. Rashidi, B., Yang, M., Jiang, P., Baranov, E., An, Z., Wang, X., Moossa, A.R., and Hoffman, R.M. A highly metastatic Lewis lung carcinoma orthotopic green fluorescent protein model. Clinical & Experimental Metastasis 18, 57-60, 2000.

 

ORGAN SPECIFIC MODELS