Organ-specific models-MetaMouse®
GFP models-OncoBrite®
Angiogenesis models-AngioMouse®
Bone metastases

Ovarian cancer models
  • Orthotopic transplantation of intact tissue
  • Metastatic sites
    • peritoneum
    • omentum
    • colon
    • contralateral ovary
    • mesentry
    • lymph nodes
    • subcutaneous tissue
    • liver
    • pancreas
    • kidney
    • diaphragm
  • Green Fluorescent Protein expression

1.   Fu, X., and Hoffman, R.M. Human ovarian carcinoma metastatic models constructed in nude mice by orthotopic transplantation of histologically-intact patient specimens. Anticancer Res. 13, 283-286, 1993.

2. Astoul, P., Colt, H.G., Wang, X., and Hoffman, R.M. Metastatic human pleural ovarian cancer model constructed by orthotopic implantation of fresh histologically-intact patient carcinoma in nude mice. Anticancer Res. 13, 1999-2002, 1993.

3. Kiguchi, K., Kubota, T., Aoki, D., Udagawa, Y., Yamanouchi, S., Saga, M., Amemiya, A., Nozawa, S., Moossa, A.R., and Hoffman, R.M. A patient-like orthotopic implantation nude mouse model of highly metastatic human ovarian cancer. Clinical & Experimental Metastasis 16, 751-756, 1998.


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