Stomach cancer models
Example: NUGC-4-GFP human stomach tumor in nude mouse. Primary tumor- red arrow, lymph node metastases - white arrows

 

Features
  • Orthotopic transplantation of intact tissue
  • Metastatic sites
    • lymph nodes
    • liver
    • lung
    • pancreas
    • adrenal gland
    • kidney
    • peritoneum
  • Green Fluorescent Protein expression

1.   Furukawa, T., Fu, X., Kubota, T., Watanabe, M., Kitajima, M., and Hoffman, R.M. Nude mouse metastatic models of human stomach cancer constructed using orthotopic implantation of histologically intact tissue. Cancer Res. 53, 1204-1208, 1993.

2. Furukawa, T., Kubota, T., Watanabe, M., Kitajima, M., and Hoffman, R.M. Orthotopic transplantation of histologically intact clinical specimens of stomach cancer to nude mice: Correlation of metastatic sites in mouse and individual patient donors. Int. J. Cancer 53, 608-612, 1993.

3. Furukawa, T., Kubota, T., Watanabe, M., Kitajima, M., and Hoffman, R.M. Differential chemosensitivity of local and metastatic human gastric cancer after orthotopic transplantation of histologically intact tumor tissue in nude mice. Int. J. Cancer 54, 397-401, 1993.

4. Inada, T., Ichikawa, A., Kubota, T., Ogata, Y., Moossa, A.R., and Hoffman, R.M. 5-FU-induced apoptosis correlates with efficacy against human gastric and colon cancer xenografts in nude mice. Anticancer Res. 17, 1965-1972, 1997.

5. Hasegawa, S., Yang, M., Chishima, T., Shimada, H., Moossa, A.R., Hoffman, R.M. In vivo tumor delivery of the green fluorescent protein gene to report future occurrence of metastasis. Cancer Gene Therapy 7, 1336-1340, 2000.

 

ORGAN SPECIFIC MODELS